Rachel Uffner Gallery opened in Fall 2008 on Orchard Street in New York City's Lower East Side. The program consists of emerging and mid-career international artists, many of whom have been included in significant museum and gallery exhibitions worldwide. The gallery first opened in a small storefront on Orchard Street in New York City’s Lower East Side in September 2008. In March 2014, the gallery reopened in a much larger bi-level building on Suffolk Street, providing artists with the opportunity to exhibit their work on a larger scale as well as to show different sides of their practice. The new space also allows for a higher number and a broader range of exhibitions. In the summer of 2019, the gallery expanded once again by merging with the storefront next door. Now, encompassing an entire building with three distinct exhibition spaces, the gallery is able to anchor their program further and provide even more space for artists, as well as increased space for special curated group shows and projects.